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KMID : 0356920120630020173
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Korean Journal of Anesthesiology
2012 Volume.63 No. 2 p.173 ~ p.176
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Seizure developed after palonosetron intravenous injection during recovery from general anesthesia -A case report-
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Park Pyung-Gul
Shin Hwa-Yong
Kang Hyun
Jung Yong-Hun
Woo Young-Cheol
Kim Jin-Yun
Koo Gill-Hoi
Park Sun-Gyoo
Baek Chong-Wha
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Abstract
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Seizure associated with antiemetics is rare. We report seizure associated with a 5-HT3 receptor antagonist in a 38 years old female. The patient underwent ureterorenoscopic lithotripsy due to left upper ureter stone. After operation, the patient complained of nausea in the postanesthetic recovery unit. In order to subside symptom, the patient was administrated 5-HT3 receptor antagonist, palonosetron, 0.075 mg intravenously. Shortly after administration of that, the patient developed generalized tonic-clonic seizures. The symptom was subsided after midazolam and thiopental sodium were injected. But 40 minutes later, seizure recurred and subsided with midazolam again. The patient recovered completely without any specific sequelae.
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KEYWORD
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Palonosetron, Seizure, 5-HT3R antagonist
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